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| Project ID/Title: | 07-13. Placenta-penetrating Nanocarriers for Improved Gene Delivery | | Advisor: | Giovanni Pauletti | | Academic Title: | Associate Professor | | Department: | Department of Pharmacy | | Department Website: | http://pharmacy.uc.edu/ | | Email: | gm.pauletti@uc.edu | | Phone: | 513-558-4552 | | Fax: | 513-558-0978 | | Graduate Program(s): | Pharmaceutical Sciences | | Co-Advisor(s): | Anil Menon, Department of Molecular Genetics | | Project Description: | The objective of this interdisciplinary Ph.D. research project is to develop innovative non-viral gene delivery systems for reproducible transfer of therapeutic DNA across the placental barrier. The central hypothesis underlying this research is that short ligand peptide sequences identified by phage display increase transport efficiency of drug delivery nanocarriers across the trophoblast barrier via transcytosis. The significance of this project is that innovative application of random peptide library screening using phage display may accelerate the development of novel, non-viral gene delivery systems to allow minimum-invasive fetal pharmacotherapy in utero while, simultaneously, reducing drug exposure to the mother because of favorable biodistribution of the therapeutic agent from the maternal to the fetal circulation. |
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