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| Project ID/Title: | 07-16. Transport Properties of the Lower Skin Layers | | Advisor: | Gerald Kasting | | Academic Title: | Professor | | Department: | Pharmacy | | Department Website: | http://pharmacy.uc.edu/ | | Email: | kastingb@ucmail.uc.edu | | Phone: | 513-558-1817 | | Fax: | 513-558-1978 | | Graduate Program(s): | Pharmaceutical Sciences | | Co-Advisor(s): | | | Project Description: | The skin is a multilaminate biological membrane of utmost importance to the health and well being of all mammalian species. It performs several key functions including thermoregulation, water conservation, immune surveillance and a barrier for entry of foreign substances into the body. While the outermost skin layer, the stratum corneum, usually provides most of the diffusion barrier, the inner layers – viable epidermis and dermis – provide the remainder of the functionality. Transport of exogenous substances across these layers is an important aspect of both immune response and systemic exposure. The proposed project will provide definitive data for diffusive transport of chemicals in the epidermis and dermis, enabling the development of improved models for topical drug delivery and dermal risk assessment. |
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