Biography

Dr. Peixuan Guo received his Ph.D. in Microbiology and Genetics in Dwight Anderson’s lab at the University of Minnesota/School of Dentistry in 1987. He was then a postdoctoral fellow with Enzo Paoletti in the Wadsworth Center of the New York State Department of Health and a visiting scientist with Bernard Moss at NIH.  He joined Purdue University in 1990, and was tenured in 1993 and became a full Professor of Molecular Virology in 1997, and was horned as Purdue Faculty Scholar since 1998. Currently, he is a professor at University of Cincinnati, serving as Dane and Mary Louise Miller Endowed Chair in Biomedical Engineering, is also the director of NIH Nanomedicine Development Center.

Dr. Guo constructed an in vitro phi29 DNA packaging motor (the most powerful biomotor constructed to date) (PNAS, 1986); discovered the motor pRNA (the viral RNA that binds ATP) (Science, 1987) and the formation of hexameric pRNA (Molecular Cell, 1998). He also demonstrated that RNA can serve as building blocks for nano-devices (Nano Letters, 2004, 2005). Other effort in Dr. Guo’s lab is the single-molecular study of phi29 motor (EMBO J 2007). His lab has assembled a home-made State-of-the-Art dual viewing system that can easily detect single-fluorophores.  His latest contribution is the use of his early discovery, the phi29 pRNA, for gene or drug delivery for the treatment of cancers and viral-related diseases such as Hepatitis B, and for the detection of pathogens and the diagnosis of diseases (Human Gene Therapy, 2005). He has chaired or been the keynote speaker at numerous symposia and international conferences. He was awarded an NIH “First Award” in 1992, the “Pfizer Distinguished Faculty Award for Research Excellence” in 1995, the “Purdue Faculty Scholar” in 1998, the “Seed Award” in 2004, 2005, 2007 and Lion Club Cancer Research Award in 2006. In both 2005 and 2006, he was selected by Foresight Nanotech Institute as a Finalist --one of the top five researchers in nanotechnology for a Feynman Prize. Dr. Guo is an editor or editorial board member for six journals, including four in nanotechnology and bionanotechnology. His work has been reported hundreds of times on radio, TV, such as ABC, NBC, and WLFI, or and other important web sites including NCI, NIH, NSF, MSNBC, and Science.

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