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Publications

Original Papers in Referred Journals

  1. Wendell, D., Jing, P., Geng, J., Subramaniam, V., Lee, T. J., Montemagno, C. D. & Guo P. 2009. Translocation of double stranded DNA through membrane adapted phi29 motor protein nanopore. Nature Nanotechnology, Advance online publication, 27 September 2009, DOI 10.1038/nnano.2009.259. [link]
  2. Zhang HM, Su Y, Guo S, Yuan J, Lim T, Liu J, Guo P, Yang D. 2009. Targeted delivery of anti-coxsackievirus siRNAs using ligand-conjugated packaging RNAs. Antiviral Res.Volume 83, Issue 3, 307-316 [link] [pdf]
  3. Lee,T.J., Zhang, H., Chang,C., Savran,C, and Guo P. 2009. Reengineering and extension of the arms of phi29 DNA packaging motor of single molecule detection. Small. In Press.
  4. Xiao F., Cai Y., Wang, J.C., Green D., Cheng R.H., Demeler, B.,and Guo, P. 2009. Adjustable Ellipsoid Nanoparticles Assembled from Re-engineered Connectors of the Bacteriophage Phi29 DNA Packaging Motor. ACS Nano. 2009 Aug 25;3(8):2163-70 [link][pdf]
  5. Li, L., Liu, J., Diao, Z., Shu, D., Guo, P., Shen G.. 2009. Evaluation of specific delivery of chimeric phi29 pRNA/siRNA nanoparticles to multiple tumor cells. Molecular Biosystems, 2009, 5, 1361 - 1368 [link] [pdf].
  6. Zhang,H., Shu,D., Browne,M., and Guo,P. 2009. Approaches for stoichiometry and distance measurement within nanometer bio-complex by dual-channel single molecule imaging. Proceedings of IEEE-NIH Life Science Systems and Applications Workshop 2009 (LISSA 2009). [link][pdf]
  7. Yi Shu, Dan Shu, Zhijuan Diao, Guanxin Shen, and Guo,P. 2009. Fabrication of polyvalent therapeutic RNA nanoparticles for specific delivery of siRNA, ribozyme and drugs to targeted cells for cancer therapy. Proceedings of IEEE-NIH Life Science Systems and Applications Workshop 2009 (LISSA 2009). [link][pdf]
  8. Feng Xiao, JinChuan Sun, Oana Coban, Peter Schoen, Joseph Che-Yen Wang, R.Holland Cheng, and Peixuan Guo. 2009. Fabrication of Massive Sheets of Single Layer Patterned Arrays Using Lipid Directed Reengineered Phi29 Motor Dodecamer. ACS Nano. 2009, 3(1).100-107 [link] [pdf]
  9. Moon JM, Akin D, Xuan Y, Ye PD, Guo P, Bashir R. 2009. Capture and alignment of phi29 viral particles in sub-40 nanometer porous alumina membranes. Biomed Microdevices. (2009) 11:135–142 [link] [pdf]
  10. Ko SH, Chen Y, Shu D, Guo P, Mao C. 2008. Reversible switching of pRNA activity on the DNA packaging motor of bacteriophage phi29. J Am Chem Soc. 130(52):17684-7 [link] [pdf]
  11. Xiao, F., H. Zhang, and P. Guo. 2008. Novel mechanism of hexamer ring assembly in protein/RNA interactions revealed by single molecule imaging. Nucleic Acids Res 36 (20):6620-6632 [link] [pdf]
  12. Fang Y, Shu D, Xiao F, Guo P, Qin PZ. 2008. Modular assembly of chimeric phi29 packaging RNAs that support DNA packaging. Biochem Biophys Res Commun. 372(4):589-94 [link] [pdf]
  13. Lee,T.J., Zhang,H., Liang,D., & Guo,P.2008. Strand and nucleotide-dependent ATPase activity of gp16 of bacterial virus phi29 DNA packaging motor. Virology 380, 69-74 [link][pdf]  
  14. 10. Chang C-L, Zhang H, Shu D, Guo P, Savran C. 2008. Bright-field analysis of Φ29 DNA packaging motor using a magneto-mechanical system. Applied Physics Letters 93:153902 [link] [pdf]
  15. Cai Y, Xiao F, Guo P. 2008. The effect of N- or C-terminal alterations of the connector of bacteriophage phi29 DNA packaging motor on procapsid assembly, pRNA binding, and DNA packaging. Nanomedicine, 4, 8-18. [link] [pdf]
  16. Zhang H, Shu D, Huang F, Guo P. 2007. Instrumentation and metrology for single RNA counting in biological complexes or nanoparticles by a single molecule dual-view system. RNA, 13, 1793–1802. [link][pdf]  
  17. Moll D and Guo P. 2007. Grouping of Ferritin and Gold Nanoparticles Conjugated to pRNA of the Phage phi29 DNA-Packaging Motor. J Nanoscience and Nanotechnology. 7: 3257–3267. [link][pdf]  
  18. DiMauro AJ, Lin D, Guo S, Karr DB, Tanner JJ, Guo P. 2007. Crystallization of phi29 spindle-shaped nano-bar anti-receptor with glycosidase domain. J Nanoscience and Nanotechnology. 7: 2616–2622.[link][pdf]  
  19. Shu D, Zhang H, Jin J, Guo P, 2007. Counting of six pRNAs of phi29 DNA-packaging motor with customized single-molecule dual-view system. The EMBO Journal 26, 527 - 537 [link][pdf]
  20. Liu H, Guo S, Roll R, Li J, Diao Z, Shao N, Riley MR, Cole AM, Robinson JP, Snead NM, Shen G, and Guo P. 2007. Phi29 pRNA Vector for Efficient Escort of Hammerhead Ribozyme Targeting Survivin in Multiple Cancer Cells. Cancer Biol. Ther. 6(5):697-704. [link] [pdf]
  21. Sun J, Cai Y, Moll D, and Guo P. 2006.  Controlling bacteriophage phi29 DNA-packaging motor by addition or discharge of a peptide at N-terminus of connector protein that interacts with pRNA. Nucleic Acids Research. 34(19):5482-90 [link] [pdf]
  22. Guo S, Huang F, and Guo P. 2006. Construction of folate-conjugated phage phi29 motor pRNA for delivery of chimeric siRNA to nasopharyngeal carcinoma cells. Gene Ther. 13,814-820. [link][pdf]
  23. Lee T and Guo P. 2006. Interaction of gp16 with pRNA and DNA for genome packaging by the motor of bacterial virus phi29.  J Mol Biol. (2006)356: 589-599.[link][pdf]
  24. Khaled A, Guo S, Li F, Guo P. Controllable Self-Assembly of Nanoparticles for Specific Delivery of Multiple Therapeutic Molecules to Cancer Cells Using RNA Nanotechnology. Nano Letters 2005; 5: 1797-1808. [link] [pdf]
  25. Guo S, Khaled A, Tschammer N and Guo P. Specific Delivery of Therapeutic RNAs to Cancer Cells via the Dimerization Mechanism of phi29 Motor pRNA. Human Gene Therapy. Sept 2005, Volume 16, No. 9: 1097-1109S. [link] [pdf]
  26. Shu D, Moll W, and Guo P. 2005. Construction of an Imitating Nanomotor Driven by Six ATP-binding RNAs of Bacterial Virus Phi29. in Electrochemical Society 2004 Proceedings - Nanoscale Devices, Materials, and Biological Systems: Fundamental and Applications.Vol.2004-13:639-652.
  27. Moll, D. & Guo, P. 2005. Translocation of nicked but not gapped DNA by the packaging motor of bacteriophage phi29. J Mol Biol. 351:100-107. [link][pdf]
  28. Xiao F, Moll W, Guo  and Guo P. 2005. Binding of pRNA to the N-terminal fourteen-amino acids of connector protein of bacterialphage phi29. Nucleic Acids Research 33(8):2640-9.[link][pdf]
  29. Guo Y, Blocker F, and Guo P. 2005. Construction of connector arrays with tetragonal to decagonal transition induced by pRNA of phi29 DNA-packaging motor. J Nanoscience and Nanotechnology. 5:856-863. [link][pdf]  
  30. Shu D, Moll D, Deng Z, Mao C, and Guo P. 2004. Bottom-up assembly of RNA arrays and superstructures as potential parts in nanotechnology. Nano Letters 4: 1717-1724. [link][pdf]
  31. Shu D., Huang L. and Guo P. 2004. A simple mathematical formula for stoichiometry quantification of viral and nanobiological assemblage using slopes of log/log plot curves. J Virol Methods. 115:19-30. [link][pdf]
  32. Shu D and Guo P.  2003. A viral RNA that binds ATP and contains a motif similar to an ATP-binding aptamer from SELEX. J Biol Chem. 278(9): 7119-7125 [link][pdf]
  33. Hoeprich S, Qi G, Guo S, Shu D, Wang Y and Guo P. 2003. Bacterial virus phi29 pRNA as a Hammerhead Ribozyme Escort to Destroy Hepatitis B Virus, Gene Ther. 10:1258-67. [link][pdf]
  34. Shu D, Huang L, Hoeprich S and Guo P.  2003. Construction of phi29 DNA-packaging RNA (pRNA) Monomers, Dimers and Trimers With Variable Sizes and Shapes as Potential Parts for Nano-devices.  Journal of Nanoscience and Nanotechnology 3:1-8 [link][pdf]
  35. Guo S, Shu D, Simon M and Guo P. 2003. Gene cloning, purification and stoichiometry quantification of phi29 anti-receptor gp12 with potential use as special ligand for gene delivery. Gene 315:145-52. [link][pdf]
  36. Huang L and Guo P. 2003. Use of acetone to attain highly active and soluble DNA packaging protein Gp16 of Phi29 for ATPase assay. Virology. Aug 1;312(2):449-457. [link][pdf]
  37. Huang L and Guo P. 2003.  Use of PEG to acquire highly soluble DNA-packaging enzyme gp16 of bacterial virus phi29 for stoichiometry quantification.  J. J. Virol Meth. 109:235-244. [link][pdf]
  38. Shu D and Guo P. 2002.  Only one pRNA hexamer but multiple copies of the DNA-packaging protein gp16 are needed for the motor to package bacterial virus phi29 genomic DNA Virology 309: 108-113. [link][pdf]
  39. Hoeprich S, Guo P. Computer Modeling of Three-dimensional Structure of DNA-packaging RNA (pRNA) Monomer, Dimer, and Hexamer of Phi29 DNA Packaging Motor. J Biol Chem. 2002 Jun 7;277(23):20794-803 [link][pdf]
  40. Mat-Arip Y, Garver K, Chen C, Sheng S, Shao Z, Guo P. 2001.Three-dimensional Interaction of Phi29 pRNA Dimer Probed by Chemical Modification Interference, Cryo-FM,and Cross-linking. J Biol Chem. 276(35):32575-84. [link][pdf]
  41. Zhang C. Trottier, M. and Guo, P.  2001 Chemical modification patterns of  active and inactive as well as  procasid-bound and unbound DNA packaging RNA of bacterial virus phi29. Virology, 281:281-293. [link][pdf]
  42. M.Trottier, Y. Mat-Arp, C. Zhang, C. Chen, S. Sheng, Z. Shao, and P. Guo. 2000. Probing the structure of monomers and dimers of the bacterial virus phi29 hexamer RNA complex by chemical modification. RNA 6(9): 1257-1266. [link][pdf]
  43. C. Chen, S. Sheng., Z. Shao, P. Guo. 2000. A Dimer as a Building Block in Assembling RNA. J. Biol. Chem.275(23): 17510-17516. [link][pdf]
  44. K. Garver and P. Guo. 2000. Mapping the inter-pRNA interaction of phage phi29 pRNA by site-specific photoaffinity crosslinking. J. Biol. Chem. 275(4): 2817-2824 . [link][pdf]
  45. Mohammad, T., C.  Chen,  P. Guo and H. Morrison. 1999. Photoinduced cross-linking of RNA by cis-ph(phen)2Cl2+ and cis-ph(phen)(phi)l2+. Bioorganic and Medicinal Chemistry Letters 9:1703-1708. [link][pdf]
  46. Aggarwal, N.,  H. HogenEsch, P. Guo, A. North, M. Suckow and S. Mittal. 1999. Biodegradable Alginate Microspheres as a Delivery System for Naked DNA. Can J. Vet. Res. 63:148-152.  [link] [pdf]
  47. Chen, C., Zhang C. and P. Guo. 1999.  Sequence requirement for hand-in-hand interaction to form hexameric RNA complex for phage phi29 DNA packaging. RNA 5:805-818. [link][pdf]
  48. Guo, P., C. Zhang, Chen, C., K. Garver, M. Trottier and  C. Chen. 1998. Inter-RNA Interaction of phage phi29 pRNA to Form a Hexameric Complex for DNA Transportation. Mol. Cell 2:149-155.  [link] [pdf]
  49. Trottier, M., Garver, K., Zhang, C. and  P. Guo. 1997. DNA-packaging pRNA as target for complete inhibition of viral assembly  in vitro  and in vivo. Nucleic Acids Symposium Series. 36:187-189.  
  50. Chen, C., Trottier, M. C. and P. Guo. 1997.  New approaches to  stoichiometry determination and mechanism investigation on RNA involved in intermediate reactions. Nucleic Acid Symp Series. 36:190-193.
  51. Chen, C. and P. Guo. 1997.  Sequential action of six DNA-packaging pRNA during phage phi29 genomic DNA translocation. J. Virology 71:3864-3871. [link]
  52. Garver, K. and P. Guo. 1997. Boundary of pRNA functional domains and minimum pRNA sequence requirement for specific connector binding and DNA packaging of phage phi29.  RNA 3:1068-1079. [link]
  53. Chen, C. and P. Guo. 1997.  Magnesium-induced conformational change of pRNA for procapsid recognition and binding during bacteriophage phi29 DNA packaging.  J. Virology 71: 495-500. [link]
  54. Trottier, M. and P. Guo.  1997. Approaches to Determine Stoichiometry of Viral Assembly Components.  J. Virology, 71:487-494. [link]
  55. Zhang, C. L., T. Tellinghuiesn  and P. Guo.  1997. Use of circular permutation to assess six bulges and four loops of DNA-packaging pRNA of bacteriophage phi29. RNA 3:315-322. [link]
  56. Huang, Q., Y. Mat-Arip, and P. Guo. 1997.  Sequencing of a 5.5-kb DNA fragment and identification of a gene coding for a subunit of the helicase/primase complex of avian Laryngotracheitis virus (ILTV). Virus Gene 15:(2): 119-121. [link]
  57. Trottier, M., C. L. Zhang, and P. Guo.  1996. Complete inhibition of virion assembly in vivo  with mutant pRNA essential for phage phi29 DNA packaging. J Virol 70:55-61. [pdf]
  58. Lee, C. S. and P. Guo.  1995. Sequential interactions of structural proteins in phage phi29 procapsid assembly. J Virol 69:5024-5032. [link][pdf]
  59. Lee, C. S. and P. Guo.  1995. In vitro assembly of infectious virions of ds-DNA phage phi29 from cloned gene products and synthetic nucleic acids. J Virol 69:5018-5023. [link]
  60. Zhang, C. L., T. Tellinghuiesn, and P. Guo.  1995. Confirmation of the helical structure of the 5’/3’ termini of the essential DNA packaging pRNA of phage phi29. RNA 1:1041-1050.  [link]
  61. Zhang, C. L., M. Trottier, and P. Guo.  1995. Circularly permuted viral pRNA active and specific in the packaging of bacteriophage phi29 DNA. Virology 207:442-451. [link][pdf]
  62. Zhang, C. L., K. Garver, and P. Guo.  1995. Inhibition of phage phi29 assembly by antisense oligonucleotides targeting viral pRNA essential for DNA packaging. Virology 211:568-576.[pdf]
  63. Scholz, E. and P. Guo. 1995. Construction of Recombinant Avian Infectious Laryngotracheitis Virus with TK Gene disrupted by ß-gal Coding Sequence. In Imm Viral Inf. Proc. 3rd Intl Cong Vet. Virol, 379-384,
  64. Guo, P., E. Scholz, B. Maloney, and E. Welniak.  1994. Construction of recombinant avian infectious laryngotracheitis virus expressing the b-galactosidase gene and DNA sequencing of the insertion region. Virology 202:771-781.
  65. Lee, C. and P. Guo.  1994. A highly sensitive system for the assay of in vitro  viral assembly of bacteriophage phi29  of Bacillus subtilis. Virology 202:1039-1042.
  66. Scholz, E., R. E. Porter, and P. Guo.  1994. Differential diagnosis of infectious laryngotracheitis from other avian respiratory disease by a simplified PCR procedure. J Virol Meth.  50:313-322.
  67. Zhang, C. . L., C. -S. Lee, and P. Guo.  1994. The proximate 5’ and 3’ ends of the 120-base viral RNA (pRNA) are crucial for the packaging of bacteriophage phi29 DNA. Virology 201:77-85.
  68. Guo, P., E. Scholz, J. Turek, R. Nordgren, and B. Maloney.  1993. Assembly pathway of avian infectious laryngotracheitis virus. Am J Vet Res 54:2031-2039.
  69. Scholz, E., E. Welniak, T. Nyholm, and P. Guo.  1993. An avian hepatoma cell line for the cultivation of infectious laryngotracheitis virus and for the expression of foreign genes with a mammalian promotor. J Virol Meth 43:273-286.
  70. Scholz, E., C. L. Zhang, and P. Guo.  1993. Transactivation of the early SV40 promoter by avian infectious laryngotracheitis virus in avian hepatoma cells. J Virol Meth 45:291-301.
  71. Lee, C. -S. and P. Guo.  1993. Tracking and elimination of a interfering polypeptide co-expressed with the vaccinia virus mRNA Capping Enzyme. Protein Expression and Purification 4:114-119.
  72. Guo, P., S. Erickson, W. Xu, N. Olson, T. S. Baker, and D. Anderson.  1991. Regulation of the phage phi29 prohead shape and size by the portal vertex. Virology 183:366-373.
  73. Guo, P., B. Rajogopal, D. Anderson, S. Erickson, and C. -S. Lee.  1991. sRNA of bacteriophage phi29 of B.subtilis mediates DNA packaging of phi29 proheads assembled in E. coli. Virology 185:395-400.
  74. Guo, P. and B. Moss.  1990. Interaction and mutual stabilization of the two subunits of vaccinia virus mRNA capping enzyme co-expressed in Escherichia coli. Proc Natl Acad Sci USA 87:4023-4027.
  75. Guo, P., S. Goebel, M. Perkus, J. Taylor, E. Norton, G. Allen, B. Languet, P. Desmettre, and E. Paoletti.  1990. Coexpression by vaccinia virus recombinants of equine herpesvirus 1 glycoproteins gp13 and 14 results in potentiated immunity. J Virol 64:2399-2406.
  76. Guo, P. 1990. Characterization of the gene and an antigenic determinant of equine herpesvirus 1 glycoprotein 14 with homology to gB-equivalent glycoprotein of other herpesvirus. Gene 87:249-255.
  77. Guo, P., S. Goebel, S. Davis, M. Perkus, B. Languet, P. Desmettre, G. Allen, and E. Paoletti.  1989. Expression of the equine herpesvirus type 1 gene encoding glycoprotein gp13 in recombinant vaccinia virus and protection of immunized animals. J Virol 63:4189-4198.
  78. Guo, P.  1988. Inhibition of novobiocin, coumermycin A, oxolinic acid, nalidixic, ethidium bromide and ATP analogue on the packaging of phi29 DNA in vitro. Virologica Sinica 2:198-205.
  79. Guo, P., C. Peterson, and D. Anderson.  1987. Prohead and DNA-gp3-dependent ATPase activity of the DNA packaging protein gp16 of bacteriophage phi29. J Mol Biol 197:229-236.
  80. Guo, P., S. Erickson, and D. Anderson.  1987. A small viral RNA is required for in vitro packaging of bacteriophage phi29 DNA. Science 236:690-694.
  81. Guo, P., S. Bailey, J. W. Bodley, and D. Anderson.  1987. Characterization of the small RNA of the bacteriophage phi29 DNA packaging machine. Nucleic Acids Res. 15:7081-7090.
  82. Guo, P., C. Peterson, and D. Anderson.  1987. Initiation events in in vitro packaging of bacteriophage phi29 DNA-gp3. J Mol Biol 197:219-228.
  83. Guo, P., S. Grimes, and D. Anderson.  1986. A defined system for in vitro packaging of DNA-gp3 of the Bacillus subtilis bacteriophage phi29. Proc Natl Acad Sci USA 83:3505-3509
Reviews
  1. Guo, P., Coban,O., Snead, N., Trebley, J., Guo, S. 2009. Engineering RNA for targeted siRNA delivery and nanomedicine. Advanced Drug Delivery Reviews.  In Press.
  2. Lee, T., Schwartz, C., and Guo, P. 2009. Construction of Bacteriophage Phi29 DNA Packaging Motor and Its Applications in Nanotechnology and Therapy. Annals of Biomedical Engineering, In Press. [pdf].
  3. Guo, P.* and Lee, T., 2007. Viral nanomotors for packaging of dsDNA and dsRNA. Molecular Microbiology 64(4), 886-903. [link][pdf]
  4. Guo P. Bacterial virus phi29 DNA-packaging motor and its potential applications in gene therapy and nanotechnology. Methods Mol Biol 2005; 300:285-324.: 285-324. [link][pdf]
  5. Guo P. RNA Nanotechnology: Engineering, Assembly and Applications in Detection, Gene Delivery and Therapy. Journal of Nanoscience and Nanotechnology 2005; 5(12): 1964-1982. [PDF]
  6. Guo P. A Special Issue on Bionanotechnology. Journal of Nanoscience and Nanotechnology 2005; 5(12): i-iii. [link]
  7. Guo P, Wei C. Quantum dots for robust and simple assays using single particles in nanodevices. Nanomedicine 2005; 2: 122-124. [link]
  8. Guo, P., 2005. Bacterial Virus phi29 DNA-Packaging Motor and Its Potential Applications in Gene Therapy and Nanotechnology. Methods Mol.Biol. 300:285-324. [link]
  9. Hall J,Moll D,Zhang,W,Guo P,Stonehouse N and Urquidi-Macdonald M, 2005. Determination of molecular size, distance, and stoichiometry of bionanoparticles using nanoscale measurement techniques. Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology, edited by H.S.Nalwa, American Scientific Publishers, Los Angeles (2005) 1, 477-493.
  10. Grigoriev D, Moll D, Hall J and Guo P. 2003. Bionanomotors. ENN-Encyclopedia of Nanoscience and Nanotechnology.  American Scientific Publishers, Stevenson Ranch. Vol 1:361-374.
  11. Guo P.  2002.  Structure and function of phi29 hexameric RNA that drives the viral DNA packaging motor.  Progress in Nucleic Acids Research 72: 415-474. [pdf]
  12. Guo P.  2002. Methods for Structural and Functional Analysis of pRNA in Bacterial Virus Phi29  DNA Packaging Motor. Acta Biochem Biophys Sin. 43(5):533-543.[link]
  13. Guo, P. and M. Trottier.  1994. Biological and biochemical properties of the small viral RNA (pRNA) essential for the packaging of the double-stranded DNA of phage phi29. Seminars in Virology 5:27-37. 
  14. Guo, P.  1994. Editor’s Introduction: Principles, perspectives, and potential applications in viral assembly. Seminars in Virology 5(1):1-3. 
  15. Guo, P. 1988 Mechanism of DNA packaging in ds-DNA bacteriophages. Virogica Sinica 2:229-2
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